{"id":8988,"date":"2018-06-05T08:32:31","date_gmt":"2018-06-05T08:32:31","guid":{"rendered":"https:\/\/mycor.iam.inrae.fr\/IAM\/?p=8988"},"modified":"2018-06-05T08:33:21","modified_gmt":"2018-06-05T08:33:21","slug":"article-scientific-reports-5","status":"publish","type":"post","link":"https:\/\/mycor.iam.inrae.fr\/IAM\/?p=8988","title":{"rendered":"Article: Scientific reports"},"content":{"rendered":"<p><a class=\"gsc_a_at\" href=\"https:\/\/www.nature.com\/articles\/s41598-018-26601-3\" data-href=\"\/citations?view_op=view_citation&amp;hl=fr&amp;user=_zC4pj4AAAAJ&amp;sortby=pubdate&amp;citation_for_view=_zC4pj4AAAAJ:dQ2og3OwTAUC\">Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor\u00a0<\/a>M Schwartz, T Perrot, E Aubert, S Dumar\u00e7ay, F Favier, P G\u00e9rardin, &#8230;Scientific Reports 8 (1), 8472<\/p>\n<h2 id=\"Abs1\" class=\"js-section-title section-title strong position-relative tighten-line-height background-gray-light pt20 pb6 pl0 pr20 standard-space-below small-space-above mq640-pt10 mq640-pb10 mq640-pl20 mq640-mt0 extend-left\">Abstract<\/h2>\n<div id=\"Abs1-content\" class=\"pl20 mq875-pl0 js-collapsible-section\">\n<p style=\"text-align: justify;\">Wood decay fungi have complex detoxification systems that enable them to cope with secondary metabolites produced by plants. Although the number of genes encoding for glutathione transferases is especially expanded in lignolytic fungi, little is known about their target molecules. In this study, by combining biochemical, enzymatic and structural approaches, interactions between polyphenols and six glutathione transferases from the white-rot fungus <i>Trametes versicolor\u00a0<\/i>have been demonstrated. Two isoforms, named TvGSTO3S and TvGSTO6S have been deeply studied at the structural level. Each isoform shows two distinct ligand-binding sites, a narrow L-site at the dimer interface and a peculiar deep hydrophobic H-site. In TvGSTO3S, the latter appears optimized for aromatic ligand binding such as hydroxybenzophenones. Affinity crystallography revealed that this H-site retains the flavonoid dihydrowogonin from a partially purified wild-cherry extract. Besides, TvGSTO6S binds two molecules of the flavonoid naringenin in the L-site. These data suggest that TvGSTO isoforms could interact with plant polyphenols released during wood degradation.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor\u00a0M Schwartz, T Perrot, E Aubert, S Dumar\u00e7ay, F Favier, P G\u00e9rardin, &#8230;Scientific Reports 8 (1), 8472 Abstract Wood decay fungi have complex detoxification systems &hellip; <a href=\"https:\/\/mycor.iam.inrae.fr\/IAM\/?p=8988\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-8988","post","type-post","status-publish","format-standard","hentry","category-academic-productions"],"_links":{"self":[{"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/posts\/8988","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8988"}],"version-history":[{"count":0,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/posts\/8988\/revisions"}],"wp:attachment":[{"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8988"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8988"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8988"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}