{"id":9247,"date":"2018-10-06T16:02:34","date_gmt":"2018-10-06T16:02:34","guid":{"rendered":"https:\/\/mycor.iam.inrae.fr\/IAM\/?p=9247"},"modified":"2018-10-06T16:03:38","modified_gmt":"2018-10-06T16:03:38","slug":"article-scientific-reports-6","status":"publish","type":"post","link":"https:\/\/mycor.iam.inrae.fr\/IAM\/?p=9247","title":{"rendered":"Article: Scientific reports"},"content":{"rendered":"<p><a class=\"gsc_a_at\" href=\"https:\/\/www.nature.com\/articles\/s41598-018-32825-0\" data-href=\"\/citations?view_op=view_citation&amp;hl=en&amp;user=eUEKPngAAAAJ&amp;sortby=pubdate&amp;citation_for_view=eUEKPngAAAAJ:D_sINldO8mEC\">A rust fungal effector binds plant DNA and modulates transcription\u00a0<\/a>MB Ahmed, KCG dos Santos, IB Sanchez, B Petre, C Lorrain, MB Plourde, &#8230;\u00a0Scientific Reports 8 (1), 14718<\/p>\n<h2 id=\"Abs1\" class=\"js-section-title section-title strong position-relative tighten-line-height background-gray-light pt20 pb6 pl0 pr20 standard-space-below small-space-above mq640-pt10 mq640-pb10 mq640-pl20 mq640-mt0 mq640-ml-20 mq640-mr-20 extend-left\">Abstract<\/h2>\n<div id=\"Abs1-content\" class=\"pl20 mq875-pl0 js-collapsible-section\">\n<p style=\"text-align: justify;\">The basidiomycete <i>Melampsora larici-populina<\/i> causes poplar rust disease by invading leaf tissues and secreting effector proteins through specialized infection structures known as haustoria. The mechanisms by which rust effectors promote pathogen virulence are poorly understood. The present study characterized Mlp124478, a candidate effector of <i>M. larici-populina<\/i>. We used the models <i>Arabidopsis thaliana<\/i>and <i>Nicotiana benthamiana<\/i> to investigate the function of Mlp124478 in plant cells. We established that Mlp124478 accumulates in the nucleus and nucleolus, however its nucleolar accumulation is not required to promote growth of the oomycete pathogen <i>Hyaloperonospora arabidopsidis<\/i>. Stable constitutive expression of <i>Mlp<\/i><i>1<\/i><i>24478<\/i> in <i>A. thaliana<\/i>repressed the expression of genes involved in immune responses, and also altered leaf morphology by increasing the waviness of rosette leaves. Chip-PCR experiments showed that Mlp124478 associats&#8217;e with the TGA1a-binding DNA sequence. Our results suggest that Mlp124478 exerts a virulence activity and binds the TGA1a promoter to suppress genes induced in response to pathogen infection.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A rust fungal effector binds plant DNA and modulates transcription\u00a0MB Ahmed, KCG dos Santos, IB Sanchez, B Petre, C Lorrain, MB Plourde, &#8230;\u00a0Scientific Reports 8 (1), 14718 Abstract The basidiomycete Melampsora larici-populina causes poplar rust disease by invading leaf tissues &hellip; <a href=\"https:\/\/mycor.iam.inrae.fr\/IAM\/?p=9247\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-9247","post","type-post","status-publish","format-standard","hentry","category-academic-productions"],"_links":{"self":[{"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/posts\/9247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9247"}],"version-history":[{"count":0,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=\/wp\/v2\/posts\/9247\/revisions"}],"wp:attachment":[{"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9247"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9247"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mycor.iam.inrae.fr\/IAM\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}